The 10 Best Enzyme Cleaners for Dogs and Cats That Tackle Even the Most Notorious Stains and Odors

Introduction

Pet ownership comes with countless joys, but it also presents challenges, especially when it comes to keeping your home clean. One of the most persistent issues for pet owners is dealing with stains and odors from accidents. Whether it’s urine, feces, vomit, or other messes, finding an effective cleaning solution is essential. Enzyme cleaners are the gold standard for tackling these issues, as they break down organic matter at the molecular level, eliminating both stains and odors completely. In this guide, we’ll explore the 10 best enzyme cleaners for dogs and cats that can handle even the toughest messes.

What Are Enzyme Cleaners and How Do They Work?

Before diving into the list, it’s essential to understand what enzyme cleaners are and how they work. Enzymes are biological molecules that speed up chemical reactions, specifically breaking down complex molecules into simpler substances. In the context of cleaning, enzyme cleaners contain specific enzymes that target and break down organic materials such as proteins, fats, and starches found in pet stains.

How Enzyme Cleaners Work:

  • Stain Removal: Enzymes break down the proteins and other organic components in stains, making them easier to remove.
  • Odor Elimination: By breaking down the molecules causing the odor, enzyme cleaners don’t just mask the smell—they eliminate it.
  • Surface Protection: Enzyme cleaners are generally safe for most surfaces, including carpets, upholstery, and hardwood floors, making them versatile for household use.

Criteria for Selecting the Best Enzyme Cleaners

When choosing the best enzyme cleaner, several factors need to be considered to ensure you’re getting an effective product:

1. Type of Stain: Different enzyme cleaners are formulated to target specific types of stains (e.g., urine, feces, vomit). Choose one that matches your needs.

2. Surface Compatibility: Ensure the cleaner is safe for use on the surfaces in your home, including carpets, hardwood floors, tiles, and upholstery.

3. Safety: Look for non-toxic, pet-safe, and eco-friendly options to ensure the safety of your pets and family.

4. Ease of Use: Consider products that are easy to apply and require minimal effort, such as spray bottles or ready-to-use formulas.

5. Odor Control: Effective enzyme cleaners should eliminate odors completely, not just mask them with fragrances.

The Top 10 Enzyme Cleaners for Dogs and Cats

1. Rocco & Roxie Professional Strength Stain & Odor Eliminator

Why It’s Great: Rocco & Roxie’s formula is one of the most popular and highly rated enzyme cleaners on the market. It’s powerful enough to eliminate tough stains and odors, yet gentle enough for use around pets and children.

Key Features:

  • Safe for carpets, upholstery, and hardwood floors
  • Chlorine-free and color-safe
  • Certified by the Carpet and Rug Institute (CRI)

Best For: Urine stains and strong odors.

2. Nature’s Miracle Advanced Stain and Odor Eliminator

Why It’s Great: Nature’s Miracle is a trusted brand in pet cleaning products, and their advanced formula is specifically designed for severe pet messes.

Key Features:

  • Works on old and new stains
  • Discourages pets from re-soiling the same area
  • Suitable for use on carpets, hard floors, furniture, and more

Best For: Multi-surface use and preventing repeat accidents.

3. Bubba’s Super Strength Commercial Enzyme Cleaner

Why It’s Great: This commercial-grade cleaner is designed to tackle the toughest stains and odors, making it perfect for high-traffic homes with multiple pets.

Key Features:

  • Can be used on carpets, upholstery, and mattresses
  • Powerful enough for commercial use but safe for home use
  • Long-lasting odor control

Best For: Heavy-duty cleaning and high-traffic areas.

4. Simple Solution Extreme Pet Stain and Odor Remover

Why It’s Great: Simple Solution’s Extreme formula is triple-strength, making it one of the most potent options available for pet messes.

Key Features:

  • Removes stains and odors from urine, feces, and vomit
  • Contains Pro-Bacteriaâ„¢ and enzyme formula
  • Available in a spray bottle for easy application

Best For: Extreme stains and strong odors.

5. Angry Orange Enzyme Cleaner & Pet Stain Remover

Why It’s Great: Angry Orange is known for its powerful citrus-based odor eliminator, and their enzyme cleaner lives up to the brand’s reputation for effectiveness.

Key Features:

  • Natural orange scent
  • Safe for use on a variety of surfaces
  • Fast-acting and easy to use

Best For: Natural odor control with a fresh citrus scent.

6. Pet Stain & Odor Miracle by Sunny & Honey

Why It’s Great: This enzyme cleaner is highly effective on a wide range of stains and odors, including those from urine, feces, vomit, and even drool.

Key Features:

  • Biodegradable, non-toxic, and pet-safe
  • Works on carpets, hardwood, leather, rugs, and more
  • Made in the USA with high-quality ingredients

Best For: Pet owners looking for an eco-friendly option.

7. TriNova Pet Stain & Odor Remover

Why It’s Great: TriNova’s enzyme cleaner is designed to be powerful yet gentle, making it safe for pets while effectively removing stains and odors.

Key Features:

  • No harsh chemicals, non-toxic formula
  • Pleasant fragrance that doesn’t just mask odors
  • Effective on both old and new stains

Best For: Pet owners seeking a mild but effective cleaner.

8. Bissell Professional Pet Urine Eliminator with Enzyme Cleaning Action

Why It’s Great: Bissell’s Professional Pet Urine Eliminator is designed to be used with their carpet cleaning machines, offering a deep clean for stubborn stains.

Key Features:

  • Combines enzyme action with professional-grade cleaning power
  • Safe for use on carpet and upholstery
  • Effective against pet urine, vomit, and feces

Best For: Deep cleaning carpets and upholstery with a machine.

9. OUT! Advanced Stain and Odor Remover

Why It’s Great: OUT! Advanced formula uses a unique combination of enzymes and pro-bacteria to tackle pet messes, including those that have set in over time.

Key Features:

  • Works on carpets, furniture, bedding, and more
  • Prevents repeat marking
  • Fast-acting and easy to apply

Best For: Older, set-in stains and persistent odors.

10. Emmy’s Best Powerful Pet Odor Remover

Why It’s Great: Emmy’s Best combines enzyme cleaning with a fresh lavender scent, making it a popular choice for pet owners who want both clean and fresh-smelling spaces.

Key Features:

  • Lavender-scented for a pleasant fragrance
  • Safe for use around pets and children
  • Effective on a wide range of organic stains

Best For: Pet owners who prefer a scented cleaner.

How to Use Enzyme Cleaners Effectively

Using enzyme cleaners correctly ensures that you get the best results. Here’s a step-by-step guide to maximize their effectiveness:

1. Blot the Area First: Before applying the enzyme cleaner, blot up as much of the mess as possible using paper towels or a clean cloth. This reduces the amount of cleaning product needed and speeds up the cleaning process.

2. Apply Generously: Don’t skimp on the enzyme cleaner. Make sure to saturate the stained area, allowing the enzymes to penetrate deep into the carpet fibers or fabric.

3. Allow Time to Work: Enzyme cleaners need time to break down organic material. Follow the product’s instructions on how long to let it sit, usually between 10 minutes to a few hours.

4. Cover the Area: For particularly stubborn stains, covering the treated area with a damp cloth can help keep the enzymes active for longer, increasing their effectiveness.

5. Blot Again and Rinse: After the enzyme cleaner has had time to work, blot the area again to remove any excess moisture. If needed, rinse the area with clean water and blot dry.

6. Repeat if Necessary: For tough or old stains, you may need to repeat the process a few times for complete removal.

Conclusion

Dealing with pet stains and odors is an inevitable part of pet ownership, but with the right enzyme cleaner, it doesn’t have to be a headache. The products listed above are among the best on the market, offering a range of solutions for various types of stains and surfaces. Whether you’re dealing with a fresh accident or a stubborn old stain, these enzyme cleaners will help you keep your home clean and odor-free.